Risk factors contributing to fascioliasis endemicity in a focus in Dakahlia governorate 1- human host

Zoonotic fascioliasis is a problem not only in Dakahlia Governorate, but also in other Egyptian Governorates. Two hundreds and twenty patients randomly selected with suggesting manifestations were examined for fascioliasis. A total of 23 [10.4%] were positive by Kato thick smears, of which 21 were from Kafr El-Hessah and two from Oweish El-Hager. The proven human fascioliasis was examined for anti -Fasciola antibodies by IHAT and ELISA [Fhes], haemoglobin level, eosinophils percent, serum bilirubin and liver function tests. IHAT gave 82.61% positive results [19/23], and ELISA gave 100% positive results [23/23]. The clinical signs ranged between splenomegaly and ascitis in 4.34% for each up to hepatomegaly in 73.91% and mild fever in 78.26% but 2 cases were asymptomatic. Mild eosinophilia and moderate anaemia were recorded with means of 11 +/- 5.8 and 10 +/- 1.3 respectively. Mean serum bilirubin was not elevated [0.91 +/- 0.51 gm/dl]. Liver function tests [AST within normal range in all cases; <40 unit /ml but one patient had ALT above normal; >45 unit/ml]

preliminary study on the relationship between trichomonas vaginalis and cervical cancer in Egyptian women

The relationship between Trichomonas vaginalis and cancer cervix was investigated by detection of T. vaginalis antibodies in the sera of 48 invasive cervical cancer patients and 100 random age matched female controls using western immunoblot technique. It was found that antibodies to T. vaginalis were detected in sera of 18.75% of cervical cancer patients compared with 5% of the controls. The increase was evident in the age group 40-49 years and of those with squamous cell carcinoma [6/9] and mainly with grades II and III. All the reactive sera of invasive cancer patients reacted strongly with T. Vaginalis surface antigen of about 109.9, 86.1, 56.2, 48.2 and 30 Kda. So, there may be an association between T. vaginalis and the risk of cervical cancer, as there was more than 3-fold increase in the prevalence of T. Vaginalis antibodies in patients with invasive cervical cancer compared with the age matched female controls. This study highlighted the importance of clinically detection of T. vaginalis infection, which is among the factors involved in the genesis and progression of cervical cancer. In addition, its treatment would aid in restricting the rising incidence of this disease